Learn About LDN

What is LDN

LDN is a safe, non-toxic, and inexpensive NON-narcotic compounded drug with MULTIPLE benefits that help regulate a dysfunctional immune system.

In 1984 Naltrexone was approved by the FDA in the USA for the treatment of opioid addiction. Used at the STANDARD dose of 50mg to 100mg per day, it is a pure antagonist at various opioid receptors.

When we talk about LOW-DOSE naltrexone we mean doses that are a 10th or less of the standard dose of Naltrexone. The most common dose used is 4.5 mg per day. Doses range from 0.001 mg – 16 mg in clinical practice.

LDN is a pure inhibitor of opioid receptors, so there is NO narcotic effect. The chemical structure is almost identical to the endorphins that we make naturally called met-enkephalin, also known as OGF or Opioid Growth Factor, and therefore, is helpful with pain control.

LDN Benefits New Jersey

What Are The Uses And Benefits Of LDN?

The results of increasing studies indicate that LDN exerts its immunoregulatory activity by binding to opioid receptors in or on immune cells and tumor cells. These new discoveries indicate that LDN may become a promising immunomodulatory agent in the therapy for cancer and many immune-related diseases.

Through its mechanism of action, LDN works to mitigate an inflammatory reaction in your body and therefore, the list of conditions it is being used for and effective for is very long. It includes but is not limited to:

  • Autoimmune diseases (including but not limited to Hashimoto’s, vitiligo, rheumatoid arthritis, Lupus, ankylosing spondylitis, just to name a few)
  • Chronic pain (including fibromyalgia, diabetic neuropathy, temporomandibular joint disorder/TMJ, and others)
  • Hair loss
  • Dermatitis/eczema
  • Meniere’s disease
  • Burning mouth syndrome
  • Eosinophilic esophagitis (EoE)
  • Myocarditis/pericarditis
  • Vasculitis
  • Gastritis
  • Inflammatory Bowel Disease/IBD (Crohn’s Disease/Ulcerative Colitis)
  • SIBO (Small Intestinal Bacterial Overgrowth)
  • IBS (Irritable Bowel Syndrome)
  • Raynaud’s phenomenon
  • Thrombocytopenic purpura (TTP)
  • Mast cell activation syndrome (MCAS)
  • Mold toxicity
  • EBV (Epstein Barr Virus)
  • Herpes/Herpes Zoster (Shingles)
  • Lyme Disease
  • Malignancies/cancers (melanoma, breast, ovarian, colon cancer, prostate cancer, etc.)
  • Alzheimer’s
  • Amyotrophic Lateral Sclerosis (ALS)
  • Brain fog
  • Chronic fatigue syndrome (CFS)
  • Migraines
  • Multiple sclerosis (MS)
  • Myasthenia gravis
  • Peripheral neuropathy
  • Postural orthostatic tachycardia syndrome (POTS)
  • Restless legs syndrome (RLS)
  • Tourette syndrome
  • Traumatic brain injury (TBI)
  • Trigeminal neuralgia
  • Alcohol use disorder
  • Anxiety
  • Depression
  • General Anxiety Disorder (GAD)
  • Hypervigilance/Panic Disorder/Phobias (including Social Phobia)
  • Obsessive Compulsive Disorder (OCD)
  • Post-Traumatic Stress Disorder (PTSD)
  • Premenstrual Dysphoric Disorder (PMDD)
  • Trichotillomania (pathologic hair pulling)
  • Sarcoidosis
  • Emphysema/COPD
  • Interstitial cystitis (IC)/Chronic UTI
  • Arthritis (including Psoriatic arthritis)
  • Polymyositis
  • Sleep disorder
  • Vasculitis
  • Endometriosis
  • Infertility/Reduced ovarian reserve (Low AMH)
  • PMS (premenstrual syndrome)/Painful periods (Dysmenorrhea)
  • Polycystic Ovary Syndrome (PCOS)
  • Recurrent vaginitis
  • Weight loss resistance

*For a more comprehensive list of diseases and for references, go to: https://ldnresearchtrust.org

What Are The Possible Side Effects And Contraindications To LDN?

1. Contraindications:

  • Patients receiving opioid analgesics.
  • Patients currently dependent on opioids, including those currently maintained on opiate agonists such as methadone or partial agonists like buprenorphine.
  • Patients in acute opioid withdrawal.
  • Patients who have received organ transplants or are on immunosuppressive medications are cautioned against use of LDN since it may counteract the effect of those medications.

2. Potential side effects:

  • Vivid dreams
  • Headache
  • Nausea/vomiting
  • Abdominal pain/decreased appetite
  • Constipation
  • Fatigue
  • Insomnia
  • Dizziness
  • Depression and/or anxiety

Is LDN FDA Approved?

Naltrexone (standard/high dose) has been FDA-approved since 1984 for opiate and alcohol addiction treatment. Since Low Dose Naltrexone is exclusively a compounded medication, like all compounded medications, it is not under the jurisdiction of the FDA and is regulated by another government agency (The Pharmacy Compounding Accreditation Board/PCAB).

Using low-dose naltrexone for the above-mentioned conditions is therefore considered “off-label”. All that being said, the FDA still recognizes its use and benefits.

What Is The First Step

The first step to determining if this treatment is best for you will be enrolling in the discovery program for evaluation. You’ll have an opportunity to meet with Dr. Kalika who will provide a thorough consultation, in which you’ll be able to ask questions and have her provide recommendations for you.

How Much Does It Cost

The cost of this treatment varies based on the dose and amount purchased. To get the most accurate quote and a full breakdown of the costs, please schedule a consultation with Dr. Kalika.

Why Choose Absolute Vitality

In today’s world people don’t just live longer but want to feel and look young longer. Absoulute Vitality is a functional medicine clinic that offers a wide range of cosmetic & functional wellness treatments. Dr. Sanna Kalika is a Board-Certified Internal Medicine physician who focuses on providing her patients with the most attentive, comprehensive, integrative care. With over two decades of experience in traditional medicine and reinforced by years of learning and practicing functional medicine, Dr. Kalika has helped innumerable patients feel better and live more vibrant, happy lives. From conversations with her patients, she realized one important fact, looking better and aging slower is an integral part of everyone’s well-being. Absoulute Vitality’s main goal is to provide our patients with a great doctor-patient relationship that can develop even stronger over the years through communication and trust.

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Absoulute Vitality offers Low Dose Naltrexone (LDN) from our boutique practice in Manalapan, NJ in Monmouth County. Schedule a consultation with us today through our website or by calling us directly and discover if Low Dose Naltrexone (LDN) is right for you. We look forward to helping you reduce inflammation, chronic pain, and much more!

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It has been fantastic to have a physician so dedicated to partnering with me in my health journey.


Dr. Kalika's approach to functional medicine is not only innovative but incredibly personalized. She took the time to understand my unique situation and crafted a treatment plan that addressed my specific needs.


Been loving all my visits at Absoulute Vitality! Had multiple service's and have more on my radar!

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Patient Resources

We’re here to help, with a number of patient resources designed to make your experience as comfortable as possible. Read through the materials below, and don’t hesitate to reach out and set up your consultation to learn more about what we can do for you.